![]() Antigen and antibody testing for histoplasmosis may be negative in some patients with active infection. Patients with histoplasmosis or other invasive fungal infections may present with disseminated, rather than localized, disease. Invasive fungal infections, including histoplasmosis, coccidioidomycosis, candidiasis, aspergillosis, blastomycosis, and pneumocystosis.Initiate treatment for latent TB prior to HUMIRA use. Test patients for latent TB before HUMIRA use and during therapy. Patients with TB have frequently presented with disseminated or extrapulmonary disease. Active tuberculosis (TB), including reactivation of latent TB.Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids.ĭiscontinue HUMIRA if a patient develops a serious infection or sepsis. Patients treated with HUMIRA are at increased risk for developing serious infections that may lead to hospitalization or death. IMPORTANT SAFETY INFORMATION for HUMIRA (adalimumab) 1
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